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Colon Cancer
Dartmouth Study Uses the Patient's Tumor to Form Vaccine
By Dross at 2010-11-29 22:45
 

A new process for creating a personalized vaccine may become a crucial tool in helping patients with colorectal cancer develop an immune response against their own tumors. This dendritic cell (DC) vaccine, developed at Dartmouth and described in a research paper published this week in the journal Clinical Cancer Research, was used after surgical resection of metastaticterm tumors to try to prevent the growth of additional metastases.

read more | 2 comments | 2218 reads

Discovery shows promise against severe side effects
By Dross at 2010-11-05 03:42
 

November 4, 2010 – (BRONX, NY) -- A team of scientists has found a way to eliminate a debilitating side effect associated with one of the main chemotherapyterm drugs used for treating colon cancer. The strategy used in their preclinical research—inhibiting an enzyme in bacteria of the digestive tract—could allow patients to receive higher and more effective doses of the drug, known as CPT-11 or Irinotecantermterm.

read more | 1492 reads

Prostate Cancer Patients are at Increased Risk of Precancerous Colon Polyps
By Dross at 2010-10-19 03:59
 

Men with prostate cancer should be especially diligent about having routine screening colonoscopies, results of a new study by

read more | 1496 reads

Muscle Wasting In Cancer Does Not Spare The Heart
By Dross at 2010-09-11 03:02
 

The wasting disease associated with some cancers that is typically seen affecting skeletal muscles can also cause significant damage to the heart, new research in mice suggests.

Before now, cachexia, characterized by muscle wasting and dramatic weight loss, was believed to spare the heart. But an Ohio State University study showed that the condition reduces heart function and changes the heart muscle structure in mice with colon cancer.

read more | 1470 reads

New Recommendations Issued for Use of Cetuximab in Colon Cancer Therapy
By Dross at 2010-07-17 00:47
 

In a report published in the July 2010 issue of the American Society for Clinical Oncology Post, new recommendations on the use of the drug cetuximabtermterm have been issued after officials halted enrollment in a phase III clinical trial in patients with spread of colon cancer into regional lymph nodes whose tumors had been surgically removed.

Based on earlier studies, cetuximab is now indicated for treatment of patients with advanced colorectal cancer whose tumors do not have a mutation in the KRAS gene.

read more | 4 comments | 1850 reads

Cost of treating colorectal cancer can vary by thousands per patient
By Dross at 2008-11-12 02:52
 

DURHAM, N.C. -- The cost of treating colorectal cancer varies widely, with newer, life-extending therapies sometimes costing tens of thousands of dollars more than older agents, according to a study led by a team of researchers in the Duke Comprehensive Cancer Center.

"The total cost of chemotherapyterm to treat colorectal cancer may differ by as much as $36,999 per patient, depending on the regimen," said Gary Lyman, M.D., an oncologist and health outcomes researcher at Duke, and senior investigator on this study. "We know that some therapies are more promising and effective, in general, than others, and cost variation raises many questions about what kind of care patients are receiving and whether this economic burden is matched by significant clinical advancements, especially with regard to quality of life."

read more | 1404 reads

Tests Could Predict Benefit From Cancer Drugs
By gdpawel at 2008-11-02 08:57
 
Markers in blood or tumor tissue may help those fighting colon, lung or pancreatic malignancies.

What if a blood test or biopsy could predict if a cancer therapy will help cure you, or only make you feel worse?

Tests like these, based on genes, proteins or other "molecular markers" may someday do just that for people battling colon, lung and pancreatic tumors, scientists reported at a news conference.

"The ultimate goal is to bring personalized medicine to reality, to identify characteristics of tumors or patients where we can make a relatively dramatic impact using targeted agents," said Dr. Bruce Johnson of the Dana-Farber Cancer Institute and Harvard Medical School, in Boston.

read more | 1 comment | 3504 reads

Dutch Authorize Manufacture of Vaccinogen's New Cancer Vaccine; License Clears Path to European Production, FDA Trial
By Dross at 2008-05-08 01:37
 

Vaccinogen Inc. said Dutch health authorities licensed it to manufacture its break-through OncoVAX anti-colon cancer vaccine, immediately clearing the path to more than $100 million of potential European sales.

The Dutch approval of the company's facility based in Emmen, The Netherlands also paves the way to its pivotal US FDA Phase IIIb clinical trial -- the final step before the vaccine can be sold in the United States.

"The facility can produce up to 3,500 vaccines annually, equivalent to $130 million in revenues," said Michael G. Hanna, Jr., Ph.D., Vaccinogen CEO. "That number only scratches the surface of potential demand for a Stage II colon cancer vaccine. One of every three patients who have their cancer removed see it return -- and the results are usually fatal."

read more | 1137 reads

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