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Melanoma
Virus kills melanoma in animal model, spares normal cells
By admin at 2013-04-24 22:56
 

Researchers from Yale University School of Medicine have demonstrated that vesicular stomatitis virus (VSV) is highly competent at finding, infecting, and killing human melanoma cells, both in vitro and in animal models, while having little propensity to infect non-cancerous cells.



"If it works as well in humans, this could confer a substantial benefit on patients afflicted with this deadly disease," says Anthony van den Pol, a researcher on the study. The research was published online ahead of print in the Journal of Virology.

read more | 3236 reads

CT and serum LDH shows promise as survival predictor for some metastatic melanoma patients
By Dross at 2013-04-17 18:05
 

Combining CT imaging findings with baseline serum lactate dehydrogenase levels is showing promise as a way to predict survival in patients with metastaticterm melanoma being treated with anti-angiogenic therapy.

read more | 3587 reads

Scientists discover melanoma-driving genetic changes caused by sun damage
By Dross at 2012-07-20 00:03
 

HOUSTON — It's been a burning question in melanoma research: Tumor cells are full of ultraviolet (UV)-induced genetic damage caused by sunlight exposure, but which mutations drive this cancer?

None have been conclusively tied to melanoma. The sheer abundance of these passenger mutations has obscured the search for genetic driver mutations that actually matter in melanoma development and progression.

read more | 5 comments | 3543 reads

A new high-resolution method for imaging below the skin using a liquid lens
By Dross at 2011-02-22 03:34
 

 University of Rochester optics professor Jannick Rolland has developed an optical technology that provides unprecedented images under the skin's surface. The aim of the technology is to detect and examine skin lesions to determine whether they are benign or cancerous without having to cut the suspected tumor out of the skin and analyze it in the lab.

read more | 19284 reads

Arthritis medication has anti skin cancer effects
By Dross at 2010-12-02 23:53
 

Arthritis sufferers rejoice, your use of the prescription medication celebrex (celexocib), a cox-2 inhibitor, could spare you from some of the sun effects that lead to basal and squamous cell carcinomaterm. According to a study published in the Journal of the National Cancer Institute Use of the drug led to a 68 percent reduction in basal cell carcinomas and a 58 percent reduction in squamous cell carcinomas in patients at high risk for skin cancer.

read more | 2125 reads

Celebrex may help prevent some non-melanoma skin cancers
By Dross at 2010-12-01 01:59
 

 

 New research shows the NSAID Celebrex may help prevent some non-melanoma skin cancers from developing in patients who have pre-cancerous actinic keratoses lesions and are at high risk for having the disease.

read more | 1 comment | 2170 reads

Laser therapy can aggravate skin cancer
By Dross at 2009-11-20 22:58
 

High irradiances of low-level laser therapy (LLLT) should not be used over melanomas. Researchers writing in the open access journal BMC Cancer studied the pain relieving, anti-inflammatory 'cold laser', finding that it caused increased tumour growth in a mouse model of skin cancer.

read more | 2067 reads

Melanoma treatment options 1 step closer
By Dross at 2009-10-21 18:22
 

A targeted chemotherapyterm for the treatment of skin cancer is one step closer, after a team of University of Alberta researchers successfully synthesized a natural substance that shows exceptional potential to specifically treat this often fatal disease.

U of A chemistry professor Dennis Hall said after three years of work, his research team has successfully produced the substance called Palmerolide A.

read more | 9 comments | 1831 reads

Resident physicians seldom trained in skin cancer examination
By Dross at 2009-10-20 22:28
 

Many resident physicians are not trained in skin cancer examinations, nor have they ever observed or practiced the procedure, according to a report in the October issue of Archives of Dermatology, one of the JAMA/Archives journals.

read more | 1664 reads

Gene required for radiation-induced protective pigmentation also promotes survival of melanoma cells
By Dross at 2008-11-26 05:52
 

Scientists have new insight into the response of human skin to radiation and what drives the most aggressive and deadly form of skin cancer. The research, published by Cell Press in the November 21st issue of the journal Molecular Cell, may be useful in the design of new strategies for prevention of malignant melanoma.

The process of tanning involves synthesis of the pigment melanin by skin cells known as melanocytes. The melanin is dispersed to neighboring skin cells, known as keratinocytes, and acts as a natural sunscreen that provides some protection against the ultraviolet (UV) radiation in sunlight. UV radiation induces melanin production in melanocytes via activation of p53 in keratinocytes and subsequent activation of proopiomelanocortin/melanocyte-stimulating hormone (POMC/MSH). POMC/MSH initiates a series of signals leading to activation of genes controlling pigment production in melanocytes.

read more | 2165 reads

Variant of Vitamin D Receptor Gene Linked to Melanoma Risk
By Dross at 2008-09-19 01:48
 

 

 

 

A new analysis indicates an association between a gene involved in vitamin D metabolism and skin cancer. Published in the November 1, 2008 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study suggests that individuals with certain variants in a vitamin D-related gene, called BsmI, may be at an increased risk of developing melanoma.

 

Research has shown that vitamin D in the body has significant protective effects against the development of cancer because it regulates cell growth, cell differentiation and cell death. This is supported by evidence that sun exposure, which helps in the production of vitamin D, can have anticancer effects.

read more | 1760 reads

History of nonmelanoma skin cancer is associated with increased risk for subsequent malignancies
By Dross at 2008-08-28 03:55
 

Individuals with a history of nonmelanoma skin cancer (NMSC) are at increased risk for other cancers, according to a study published in the August 26 online issue of the Journal of the National Cancer Institute.

Previous studies have documented that people who have had nonmelanoma skin cancer were at increased risk for developing melanoma, but it is less well-established whether they were also at risk for cancers that do not involve the skin.

In the current study, Anthony Alberg, Ph.D., of the Medical University of South Carolina and colleagues analyzed data from a prospective cohort study called CLUE II, which was established in Washington County, Md., in 1989. Alberg's team compared the risk of malignancies in 769 individuals who had been diagnosed with nonmelanoma skin cancer and 18,405 individuals with no history of the disease during a 16-year follow-up period.

read more | 2143 reads

NYU researchers demonstrate activity of mebendazole in metastatic melanoma
By Dross at 2008-08-08 20:38
 

NEW YORK, August 6, 2008 – Researchers at the NYU Cancer Institute and the Ronald O. Perelman Department of Dermatology have identified mebendazole, a drug used globally to treat parasitic infections, as a novel investigational agent for the treatment of chemotherapyterm-resistant malignant melanoma.

Because most patients with metastaticterm melanoma fail to respond to available therapies, the discovery of a viable investigational treatment with an established safety profile could address a serious unmet need in oncology. Effectively sidestepping the prohibitive costs and long lead times typically required to discover new cancer medicines, the NYU team screened a library of already approved drugs for activity against the most deadly form of skin cancer.

read more | 2935 reads

Inherited melanoma risk: What you do know does help you
By Dross at 2008-06-18 20:53
 

Salt Lake City—When people know the results of genetic tests confirming they have inherited an increased risk of developing melanoma, they follow skin cancer screening recommendations more proactively—much like those who have already been diagnosed with the potentially deadly disease, according to results of a study completed at the University of Utah's Huntsman Cancer Institute. and published in the June issue of Cancer Epidemiology, Biomarkers & Prevention.

Tests for mutations in the CDKN2A gene can reveal a reason that melanomas "run" in families. The study evaluated the intent to follow, and the actual practice of, skin cancer early detection methods by members of families that carry CDKN2A gene mutations. Study participants were drawn from a group of Utahns who participated in the original "CDKN2A gene hunt" 10 to 12 years ago. They already knew that their family history might put them at increased risk for melanoma, and they had previously received melanoma prevention and screening education.

read more | 1739 reads

New combination therapy safe, promising for melanoma patients
By Dross at 2008-06-02 22:09
 

CHICAGO, June 1 – The combination of two different biotherapies may be beneficial for patients with inoperable melanoma, according to a University of Pittsburgh Cancer Institute (UPCI) study presented at the 44th annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Researchers in the melanoma and skin cancer program at UPCI combined two biotherapies – treatments that stimulate the immune system to fight cancer – and found the results promising in terms of anti-tumor effects and tolerable in terms of toxicity. High-dose interferon alfa-2b, a standard treatment for metastaticterm skin cancer, and tremelimumab, an antibodyterm thought to instigate the body’s immune system to attack tumors, were combined for the first time in this phase 2 clinical trial.

read more | 3 comments | 2043 reads

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