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Renal
Glowing dye improves cancer removal in kidney
By Dross at 2007-06-07 08:37
 

A new way to provide clear images of cancerous tumors in the kidney during surgery promises to help physicians preserve as much kidney function as possible while still removing all the malignant tissue – a significant advance as doctors discover that saving as much healthy kidney tissue as possible is crucial for the future health of cancer patients.

Results from a small pilot study were presented at the recent American Urological Association’s annual meeting, giving surgeons a sneak peek at a new imaging process that gives healthy kidney tissue a fluorescent glow, clearly differentiating it from cancerous tissue. This glow assists surgeons in the accurate removal of cancerous tissue during a partial nephrectomy, or the removal of a portion of the kidney.

read more | 1958 reads

Doctors conclude temsirolimus is effective new treatment for advanced renal cell carcinoma
By Dross at 2007-05-31 22:34
 

The results of a phase III, randomized clinical study involving patients with advanced renal cell carcinomaterm and poor prognostic features show temsirolimusterm improved overall survival when compared to the current treatment for this stage of disease. The study, led by Gary R. Hudes, M.D., director of the Genitourinary Malignancies Program at Fox Chase Cancer Center, is published in the May 31 issue of the New England Journal of Medicine.

A total of 626 patients with renal cell carcinoma (RCC) were enrolled in the study and received one of three treatments – a new drug called temsirolimus, an older drug called interferon, or both the new and old drugs together. The patients who received temsirolimus alone survived longer than those who received interferon, the usual or ‘standard’ treatment for this disease.

read more | 1310 reads

EntreMed Starts Phase II Clinical Trial of Panzem with Sutent for Kidney Cancer Patients
By HCat at 2007-03-13 03:58
 

    EntreMed, Inc has commenced a Phase 2 trial to evaluate the safety and efficacy of Panzem (2-methoxyestradiol; 2ME2) alone or in combination with Sutenttermterm (sunitinibterm) in patients with metastaticterm renal cell carcinomaterm. The University of Wisconsin, Paul P. Carbone Comprehensive Cancer Center will be the main center conducting the trial under the guidance of Dr. Glenn Liu. The trial will investigate Panzem’s potential to treat patients who are progressing on sunitinib.

     Panzem NCD uses Elan Drug Delivery's (Elan) NanoCrystal Colloidal Dispersion (NCD) technology, a technology that is being used in marketed pharmaceuticals. The NCD technology produces nanometer-sized particles, which are up to 500 times smaller than particles manufactured by conventional milling techniques. Panzem NCD works by blocking the VEGFterm receptor and by inhibiting HIF-1alpha. The theory behind Panzem’s anti-tumor effects is that renal cell cancers are frequently associated with VEGF and PDGF overexpression involving a HIF-1alpha mechanism. It is thought that patients who progress through the tyrosine kinase inhibitor response, such as those on the tyrosine kinase inhibitor sunitinib, have an increase in HIF-1alpha expression to compensate for the kinase inhibition in order to continue tumor growth. Dr. Liu has stated that this trial will test this hypothesis. Panzem NCD is also currently in Phase 2 clinical trials for brain, ovarian, carcinoid, and prostate cancers as well as in Phase 1 study in metastatic breast cancer.

read more | 6160 reads

Bayer and Onyx announce pivotal Nexavar kidney cancer study published in NEJM
By Dross at 2007-01-12 05:44
 

 

 

Bayer Pharmaceuticals Corporation (NYSE: BAY) and Onyx Pharmaceuticals, Inc. today announced that the New England Journal of Medicine has published their pivotal Phase III trial demonstrating that Nexavartermterm (sorafenibterm) tablets doubled median progression-free survival (PFS) in patients with advanced renal cell carcinomaterm (RCC), or kidney cancer. The data, as assessed by independent radiologic review, are from the Treatment Approaches in Renal Cancer Global Evaluation Trial (TARGET) the largest randomized controlled trial ever conducted in advanced RCC. "Historically, patients with kidney cancer have had limited treatment options and there has been a particularly critical need for new therapies to help patients with advanced disease," said co-principal investigator Ronald Bukowski, M.D., Director of the Experimental Therapeutics Program of The Cleveland Clinic Taussig Cancer Center in Cleveland, OH. "This landmark study demonstrated the efficacy, tolerability and clinical benefit of Nexavar, which has rapidly become a valuable weapon against this devastating disease." Based on these data, Nexavar was granted U.S. Food and Drug Administration (FDA) approval for the treatment of patients with advanced RCC, or kidney cancer, on December 20, 2005. Since then, Nexavar has been approved in nearly 50 countries. "Nexavar was the first new drug approved for patients with advanced kidney cancer in over a decade," said Bill Bro, President and Chief Executive Officer of the Kidney Cancer Association (KCA). "With the advent of targeted therapies such as Nexavar, there has been remarkable change patients are experiencing improved outcomes without the toxic effects traditionally associated with chemotherapyterm."

read more | 2131 reads

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