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lung cancer
Geron’s GRN163L Headed to Phase I Clinical Trials in Lung Cancer Patients
By HCat at 2007-02-17 08:26
 

    Geron Corporation has published preclinical data on GRN163L indicating anti-tumor and anti-metastaticterm activity. Released in this month’s Cancer Research, the new study ascribes the anti-metastatic effects of GRN163L to its unique structure, and not it known human telomerase RNA (hTR) inhibition. By successive shortening of this oligonucleotide (specifically N3’ to P5’ Thio-Phosphoramidate), the authors show that cell adhesion in a lung cell line is reduced due the structural aspects of GRN163L and not is inhibitory effect on hTR. Also, in mice models of metastatic lung cancer, the researchers show a reduced tumor burden in mice treated with GRN163L upon inoculation with the cancer cells.

read more | 3952 reads

Lung cancer rates higher among female nonsmokers than previously
By Dross at 2007-02-09 21:37
 

STANFORD, Calif. - Not all lung cancer is due to a lifetime of smoking cigarettes. Sometimes the diagnosis is a mystery, and the stigma surrounding the disease makes it hard for patients to talk about. Now, researchers at the Stanford University School of Medicine and the Northern California Cancer Center have taken the first steps toward analyzing why people who never smoked get lung cancer.

 

Their data, to be published in the Feb. 10 issue of the Journal of Clinical Oncology, shows that never-smokers get lung cancer more often than thought, with women even more at risk than men.

read more | 981 reads

Lung Cancer
By Dross at 2007-02-09 07:59

The Lungs

 

The lungs, a pair of sponge-like, cone-shaped organs, are part of the respiratory system. The right lung has three sections, called lobes; it is a little larger than the left lung, which has two lobes. When we breathe in, the lungs take in oxygen, which our cells need to live and carry out their normal functions. When we breathe out, the lungs get rid of carbon dioxide, which is a waste product of the body's cells.

read more | 9053 reads

Do cigarette warning labels work -- results from 4 countries
By Dross at 2007-02-06 21:49
 

    As the second leading cause of death in the world, cigarette smoking is a preventable behavior. Most countries require warnings about health risks on every package, but the effectiveness of these warnings depends upon the design and the "freshness" of the messages. In a multi-country study published in the March 2007 issue of the American Journal of Preventive Medicine, researchers found that more prominent text messages were more effective and graphic pictures even more so in affecting smokers' behaviors. Recent changes in health warnings were also associated with increased effectiveness, while health warnings on US packages, which were last updated in 1984, were associated with the least effectiveness.

read more | 582 reads

Multiple Cancer Types treated with Photodynamic Therapy for Tumor Ablation
By HCat at 2007-01-09 03:04
 

    Photodynamic therapy (PDT) is more than 25 years old, yet this cancer therapy is now becoming more widely used in multiple cancer treatment areas. PDT uses an injectable drug (usually photofrin) that is light sensitive to certain wavelengths. When this photosensitizer is hit with light at the particular wavelengths, a chemical-light reaction occurs in which numerous oxygen radicals are formed. These oxygen radicals cause damage and death to cells, inducing apoptosis and necrosis to the surrounding tissue while also initiating the immune and inflammation response within the body. To specify where the damage occurs, the light source is inserted into a fiber optic wire within a needle. The needle is then guided to the site of the cancer through various imaging techniques such as computed tomographic (CT) imaging or magnetic resonance imaging (MRI).

read more | 2435 reads

New England Journal of Medicine Avastin in Lung Cancer
By admin at 2006-12-19 03:00
 

New England Journal of Medicine Publishes Data from Pivotal Study of Avastinterm Plus Chemotherapyterm in Most Common Type of Lung Cancer

 

 Genentech, Inc. (NYSE-DNA) announced today the publication of data from a pivotal Phase III clinical trial in the New England Journal of Medicine showing that Avastin(R) (bevacizumabtermterm) in combination with paclitaxel and carboplatin chemotherapy significantly improved overall survival in patients with unresectable, locally advanced, recurrent or metastaticterm non-squamous, non- small cell lung cancer (NSCLC), the most common type of lung cancer.

read more | 1 comment | 2873 reads

New Survival Study of Vandetanib (ZACTIMA(TM), ZD6474) in Patients With Advanced Lung Cancer
By admin at 2006-11-18 06:28
 
<p>Â*Â*Â*Â* <strong>First </strong>Patient Enrolled in Phase III International Randomised, Double-Blind, Placebo-Controlled Study of <strong>Vandetanib </strong>for Non-Small Cell Lung Cancer (NSCLC) </p><p>&nbsp;</p><p>After Failure of EGFR TKI Therapy AstraZeneca today announced the start of enrolment into a <strong>new </strong>Phase III study of the novel once-daily oral anti-cancer drug vandetanib (ZACTIMA(TM), ZD6474) as third/fourth line treatment for patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) who have progressed following EGFR TKI therapy. </p><p>&nbsp;</p>
read more | 3049 reads

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